Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice

Table 1

The effect of CCME on serum marker enzymes (ALAT, ASAT, and ALP) and billirubin in iron overloaded mice.

Treatment	ALAT		ASAT		ALP		Billirubin
	Unit/L	% change	Unit/L	% change	Unit/L	% change	Unit/L	% change
B	19.32±1.85	—	28.18±1.48	—	143.49±5.76	—	1.16±0.05	—
C	45.64±4.26^X2	136.24	69.25±7.61^X2	145.69	357.59±12.45^X3	149.21	4.25±0.58^X2	265.48
S50	38.35±3.37^X2Y2	98.5	56.74±6.18^X2Y1	101.3	353.11±20.01^X3	146.08	4.22±0.4^X2	262.53
S100	36.08±1.17^X2Y1	86.74	53.95±4.84^X1Y3	91.39	338.43±10.85^X2	135.84	3.98±0.24^X2	241.88
S200	34.86±1.49^X3Y1	80.42	51.95±1.38^X3Y1	84.31	271.26±24.43^X2Y1	89.04	3.27±0.26^X2Y1	180.82
D	23.55±1.39^X2Y2	21.88	44.68±5.52^X1Y2	58.49	151.58±9.92^Y3	5.63	1.60±0.12^X2Y1	37.16

B: Normal mice; C: iron overload control; S50: iron overload + CCME (50 mg/kg b.w.); S100: iron overload + CCME (100 mg/kg b.w.); S200: iron overload + CCME (200 mg/kg b.w.); D: iron overload + desirox (20 mg/kg b.w.).
Values are mean ± SD of six observations.
X: significant difference from normal mice (B) group (X1: 𝑃≤0.05; X2: 𝑃≤0.01 and X3: 𝑃≤0.001).
Y: significant difference from iron overloaded (C) group (Y1: 𝑃≤0.05; Y2: 𝑃≤0.01; Y3: 𝑃≤0.001).