Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice

Table 2

The effect of CCME on antioxidant enzymes (SOD, CAT, and GST) and nonenzymatic antioxidant, GSH in iron overloaded mice.

Treatment	SOD		CAT		GST		GSH
	Unit/mg protein	% change	Unit/mg protein	% change	Unit/mg protein	% change	𝜇g/mg protein	% change
B	0.62 ± 0.05	—	21.55 ± 2.24	—	7.19 ± 0.71	—	0.48 ± 0.01	—
C	0.14 ± 0.07^X3	77.04	10.29 ± 0.73^X3	52.25	2.16 ± 0.51^X3	70.02	0.32 ± 0.01^X3	32.36
S50	0.26 ± 0.04^X3Y1	58.58	10.59 ± 0.34^X3	50.83	3.49 ± 0.67^X3Y2	51.45	0.42 ± 0.02^X3Y3	10.85
S100	0.31 ± 0.07^X3Y2	50.72	11.81 ± 0.71^X3Y1	45.21	4.87 ± 0.57^X3Y3	32.21	0.45 ± 0.02^Y3	5.63
S200	0.32 ± 0.05^X3Y1	48.95	15.14 ± 0.77^X2Y3	29.7	4.98 ± 0.68^X1Y2	30.77	0.46 ± 0.01^X1Y3	3.55
D	0.39 ± 0.06^X3Y2	36.59	18.97 ± 0.81^X1Y3	11.97	3.13 ± 0.53^X3Y1	56.47	0.39 ± 0.05^X3Y3	18.37

B: Normal mice; C: iron overload control; S50: iron overload + CCME (50 mg/kg b.w.); S100: iron overload + CCME (100 mg/kg b.w.); S200: iron overload + CCME (200 mg/kg b.w.); D: iron overload + desirox (20 mg/kg b.w.).
Values are mean ± SD of six observations.
X: significant difference from normal mice (B) group (X1: 𝑃≤0.05; X2: 𝑃≤0.01 and X3: 𝑃≤0.001).
Y: significant difference from iron overloaded (C) group (Y1: 𝑃≤0.05; Y2: 𝑃≤0.01; Y3: 𝑃≤0.001).