Figure 4: Oxaliplatin and SYY cotreatment resulted in a smaller tumor volume and a lower percentage of pulmonary metastasis than oxaliplatin treatment alone. (a) Treatment with low-dose SYY (2 g/kg) did not significantly inhibit tumor growth or decrease the incidence of pulmonary metastasis. Treatment with 4 g/kg SYY decreased the number of pulmonary metastasis nodules but did not inhibit tumor growth. In contrast, high-dose SYY (8 g/kg) treatment significantly inhibited tumor growth and pulmonary metastasis. (b) Cotreatment with oxaliplatin and SYY (4 g/kg) reduced tumor volume, decreased the percentage of pulmonary metastasis, and prolonged survival compared with oxaliplatin treatment alone.