Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

Figure 1

Topical apigenin reduces ear thickness in acute murine dermatitis models. Acute irritant contact dermatitis and allergic contact dermatitis models were established as described in Materials and Methods. 20 μL of 0.1% apigenin in ethanol or ethanol alone was applied to both surfaces of the right or left ear, respectively, 45 min and 2 hours following TPA or oxazolone challenge. Ear thickness was measured with a digital caliper (Mitutoyo, Tokyo, Japan) before and 20 hours after challenge with oxazolone or TPA application. The dotted line represented the normal ear thickness. Numbers and significances are indicated in the figures.