Research Article
Effects of Extracts from Trifolium medium L. and Trifolium pratense L. on Development of Estrogen Deficiency-Induced Osteoporosis in Rats
Table 1
Effects of Trifolium medium L. (TM) and Trifolium pratense L. (TP) extracts on the body mass gain, mass of estrogen-dependent organs, and serum levels of estradiol and total cholesterol in ovariectomized (OVX) rats.
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The lyophilized extracts from TM or TP at doses corresponding to 10 and 20 mg/kg of isoflavone aglycones daily (TM10, TP10 and TM20, TP20, resp.), or estradiol (0.2 mg/kg daily), were administered orally to OVX rats for 4 weeks. Results are presented as the mean ± SEM (). One-way ANOVA followed by Duncan’s test or, when appropriate, Kruskal-Wallis ANOVA followed by Mann-Whitney test was used for evaluation of the significance of the results. *, **, ***—significantly different from sham-operated control rats. ●, ●●, ●●●—significantly different from OVX control rats. |