Table 4: Analyses of clinical comprehensive effect.

TrialsIntervention (n/N)Control (n/N)RR [95% CI]P Value

Xiaoyao powder versus antidepressants
Xiaoyao powder versus amitriptyline141/4225/271.05 [0.94, 1.18]0.37
Danzhi Xiaoyao powder versus maprotiline128/3230/310.90 [0.78, 1.05]0.18
Guipi Xiaoyao powder versus venlafaxine194/10086/1001.09 [1.00, 1.20]0.06
Modified Xiaoyao powder versus amitriptyline129/3028/301.04 [0.92, 1.16]0.55
Danzyhih Xiaoyao decoction versus fluoxetine129/3422/271.05 [0.83, 1.31]0.69
Xiaoyao powder versus fluoxetine266/7561/751.08 [0.94, 1.24]0.25

Meta-Analysis7287/313252/2901.05 [1.00, 1.11]0.07

Xioayao powder plus antidepressants versus antidepressants
Xiaoyao pills/powder plus amitriptyline versus amitriptyline256/6045/601.24 [1.06, 1.46]0.008
Danzhi Xiaoyao decoction/powder plus fluoxetine versus fluoxetine251/6638/661.34 [1.05, 1.72]0.02
Xiaoyao pills plus imipramine versus imipramine126/3025/291.01 [0.82, 1.23]0.96
Xiaoyao pills plus fluoxetine versus fluoxetine256/7154/660.97 [0.82, 1.14]0.69
Danzhi Xiaoyao powder plus amitriptyline versus amitriptyline138/4028/381.29 [1.05, 1.58]0.01
Xiaoyao pills plus citalopram versus citalopram128/3028/301.00 [0.87, 1.14]1.00
Xiaoyao pills plus doxepin versus fluoxetine132/3529/331.04 [0.88, 1.22]0.63
Danzhi Xiaoyao powder plus clomipramine versus clomipramine130/3325/331.20 [0.96, 1.50]0.11
Modified Xiaoyao pills plus amitriptyline versus fluoxetine129/3230/320.97 [0.84, 1.12]0.64
Modified Xiaoyao powder plus amitriptyline versus amitriptyline131/3330/331.03 [0.90, 1.19]0.64
Xiaoyao powder plus doxepin versus doxepin19/1210/120.90 [0.60, 1.36]0.62

Meta-Analysis14386/442342/4321.10 [1.04, 1.17]0.001