Table 5: Analyses of score of HAMD.

TrialsWMD [95% CI]P value

Xiaoyao powder versus antidepressants
Danzhi Xiaoyao powder versus maprotiline22.39 [−0.55, 5.33]0.11
Modified Xiaoyao powder versus amitriptyline11.11 [−0.21, 2.43]0.10
Xiaoyao powder versus fluoxetine1−3.30 [−6.07, −0.53]0.02

Meta-Analysis [FEM]40.59 [−0.51, 1.70]0.29

Meta-Analysis [REM]40.43 [−2.14, 2.99]0.74

Xiaoyao powder plus antidepressants versus antidepressants
Xiaoyao pills plus fluoxetine versus amitriptyline10.06 [−1.50, 1.62]0.94
Xiaoyao pills plus fluoxetine versus paroxetine11.88 [0.20, 3.56]0.03
Danzhi Xiaoyao decoction/powder plus fluoxetine versus fluoxetine2−0.18 [−0.49, 0.13]0.25
Xiaoyao pills plus imipramine versus imipramine1−0.10 [−2.35, 2.15]0.93
Xiaoyao pills plus fluoxetine versus fluoxetine3−1.41 [−2.17, −0.65]0.0003
Danzhi Xiaoyao powder plus amitriptyline versus amitriptyline1−5.84 [−8.76, −2.92]<0.0001
Xiaoyao pills plus citalopram versus citalopram1−0.30 [−2.06, 1.46]0.74
Xiaoyao pills plus doxepin versus fluoxetine1−0.88 [−1.38, −0.38]0.0006
Modified Xiaoyao pills plus amitriptyline versus fluoxetine10.17 [−1.29, 1.63]0.82
Xiaoyao powder plus doxepin versus doxepin1−0.80 [−4.84, 3.24]0.70
Modified Xiaoyao powder plus amitriptyline versus amitriptyline1−0.76 [−1.16, −0.36]0.0002

Meta-Analysis [FEM]14−0.51 [−0.71, −0.31]<0.00001

Meta-Analysis [REM]14−0.69 [−1.25, −0.13]0.02

FEM: fixed effects model, REM: random effects model.