UPLC-QTOF/MS Analysis of Alkaloids in Traditional Processed Coptis chinensis Franch.

Table 1

Identified compounds in C. chinensis Franch. by UPLC-QTOF/MS.

Peak no.	𝑡𝑅 (min)	Identified compounds	Molecular formula	[M+H]^+  𝑚/𝑧			Reference
				Mean measured mass (Da)	Theoretical exact mass (Da)	Mass error (ppm)
1	1.79	Magnoflorine	C20H23NO4	342.1703	342.1705	−0.6	[13–15]
2	3.32	Groenlandicine	C19H15NO4	322.1064	322.1079	−4.7	[14]
3	3.81	Berberastine	C20H17NO5	352.1184	352.1185	−0.3	[14]
4	3.71	Lincangenine/stephabine	C21H21NO5	368.1506	368.1498	2.2	[16]
5	4.02	Demethyleneberberine	C19H17NO4	324.1220	324.1236	−4.9	[17]
6	4.32	Lycoranine B	C18H13NO4	308.0903	308.0923	−6.5	[18]
7	4.50	Jatrorrhizine/columbamine	C20H19NO4	338.1386	338.1392	−1.8	[13, 14]
8	4.66	Epiberberine	C20H17NO4	336.1228	336.1236	−2.4	[13, 14]
9	4.95	Coptisine	C19H13NO4	320.0915	320.0923	−2.5	[13, 14]
10	5.81	Thalifendine/berberrubine	C18H15NO4	322.1070	322.1079	−2.8	[14]
11	6.68	Palmatine	C21H21NO4	352.1556	352.1549	2.0	[13, 14]
12	7.01	Berberine	C20H17NO4	336.1236	336.1236	0	[13, 14]
13	8.90	Dihydrochelerythrine	C21H19NO4	350.1394	350.1392	0.6	[19]