A Systematic Review and Meta-Analysis of Efficacy, Cost-Effectiveness, and Safety of Selected Complementary and Alternative Medicine for Neck and Low-Back Pain
Table 4
Summary of findings of spinal manipulation for low-back pain (only pain and functional outcomes).
Duration and cause of pain
Outcomes
GRADE*
Findings
Manipulation versus no treatment
Acute/subacute nonspecific
Pain intensity score (0 to 5)
Low Design: RCT ROB: Medium Consistency: NA (one trial) Directness: yes
In one trial [97], there was a significantly lower immediate posttreatment pain intensity in the manipulation group (change from 2.8 to 1.0; ) compared to “no treatment” group (change from 2.0 to 2.1, ).
Acute/subacute specific
NA
Insufficient No trial
NA
Mixed nonspecific
Pain intensity score (VAS)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
In one trial [98], manipulation showed significant reduction (from baseline) in immediate/short-term posttreatment pain intensity (VAS: 12.20 versus 10.40, ), while the “no treatment” group did not experience significant reduction in pain intensity ().
Mixed specific
NA
Insufficient No trial
NA
Chronic or Unknown (nonspecific and specific)
NA
Insufficient No trial
NA
Manipulation versus placebo
Acute/subacute, nonspecific
Pain intensity score (VAS)
Moderate Design: RCT ROB: Medium Consistency: yes Directness: yes
Four trials [97, 99, 101, 211] showed significant improvements for manipulation in reducing immediate or short-term posttreatment pain. For example, in one trial [211], manipulation was significantly superior to placebo at short-term followup (four-point VAS; ). Intermediate-term posttreatment data of the same trial showed no significant difference between the groups. In another trial [101], manipulation showed significantly better immediate-term posttreatment pain intensity (percentage of pain-free subjects: 92.0% versus 25.0%, ).
Oswestry Disability Index
Low Design: RCT ROB: Medium Consistency: NA (one trial) Directness: yes
One trial [99] showed no between-group differences in the immediate and short-term posttreatment follow-ups.
Acute/subacute specific
NA
Insufficient No trial
NA
Chronic nonspecific
Pain intensity score (VAS)
Low Design: RCT ROB: Medium Consistency: no Directness: yes
In two trials [102, 211], manipulation was significantly better than placebo. In a third trial [103], the immediate posttreatment pain intensity improved more in the manipulation group (1.3 versus 0.7) and in the short-term posttreatment (2.3 versus0.6). There was a significant change within the manipulation group but not within the placebo group. The value for between-group comparison was not reported and therefore the between-group significant difference was not assumed.
Oswestry Disability Index
Low Design: RCT ROB: Medium Consistency: NA (one trial) Directness: yes
In one trial [102], manipulation was significantly better than placebo immediately posttreatment ( versus , ), but the difference in the short-term posttreatment was not statistically significant ( versus , ).
Chronic specific
NA
Insufficient No trial
NA
Mixed nonspecific
Pain intensity score (VAS)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
One trial [104] showed that immediate posttreatment improvement was numerically greater in the manipulation group (numerical data not reported, and statistical test results were not provided).
Mixed specific
NA
Insufficient No trial
NA
Unknown (specific, nonspecific)
NA
Insufficient No trial
NA
Manipulation versus pain medication
Acute/subacute, nonspecific
Pain intensity score (VAS)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
One trial showed a nonsignificant advantage of manipulation at the immediate posttreatment followup [211]. This advantage was not sustained at the short- and intermediate posttreatment followups (numerical data not reported, and statistical test results were not provided).
Low Design: RCT ROB: High Consistency: yes Directness: yes
Two trials [69, 70] showed significantly greater pain reductions with spinal manipulation. The median (IQR) pain intensity went from 5 (4 to 8) to 3 (0 to 7) () with manipulation, and from 5 (3 to 8) to 5 (2 to 7) () with medication [52]. In the other trial, the change was −2.5 (95% CI: −5.0, −21) in the manipulation group and +0.3 (95% CI: −1.0, 1.7) in the medication group [70].
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
One trial [211] showed that spinal manipulation was not significantly different from medication. Subjective score with manipulation were 2.6 and 4.3 in the short- and intermediate-term. Subjective score with medication were 2.2 and 4.0 in the short- and intermediate-term. (Statistical test results were not provided).
Oswestry Disability Index
Low Design: RCT ROB: High Consistency: yes Directness: yes
Two trials [69, 70] showed significantly greater mean reduction in disability in the manipulation versus pain medication group immediately after treatment (50% [69] and 30.7% [70]).
Chronic specific
NA
Insufficient No trial
NA
Mixed or unknown (specific, nonspecific)
NA
Insufficient No trial
NA
Manipulation versus physiotherapy
Acute/subacute, nonspecific
Pain intensity score (VAS)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
One trial [211] showed better scores with manipulation at the immediate-, short- and intermediate posttreatment followups (Numerical data not reported, and statistical test results were not provided).
Acute/subacute, specific
NA
Insufficient No trial
NA
Chronic nonspecific
Pain intensity score (VAS)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
One trial [211] showed better scores with physiotherapy versus manipulation at the immediate-, short- and intermediate posttreatment followups (numerical data not reported, and statistical test results were not provided).
Chronic specific
NA
Insufficient No trial
NA
Mixed nonspecific
Pain intensity score (11-point pain scale)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
In one trial [105], no significant differences were found in short-term posttreatment effects between manipulation and physiotherapy (McKenzie technique based on diagnoses of derangement, dysfunction or postural syndromes).
Roland-Morris Disability score
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
In one trial [105], there was no significant difference between manipulation and physiotherapy (McKenzie technique based on diagnoses of derangement, dysfunction or postural syndromes) in the short-term posttreatment effects.
In one trial [106], high or low velocity spinal manipulation was not significantly different from minimal conservative medical care. Mean VAS score difference between high velocity manipulation and usual care was 4.0 (95% CI: −4.0, 12.0), whereas this difference between low velocity manipulation and usual care was 5.8 (95% CI: −2.3 to 14.0).
One trial [106] showed that manipulation was significantly more effective than medical care alone in improving disability at immediate, short-, or intermediate-term posttreatment followup. The adjusted RMDQ mean change from baseline in the high and low velocity manipulation and medical care groups were 2.7 (95% CI: 2.0, 3.3), 2.9 (95% CI: 2.2, 3.6), and 1.6 (95% CI: 0.5, 2.8), respectively.
Mixed specific
NA
Insufficient No trial
NA
Acute, chronic or unknown (specific, nonspecific)
NA
Insufficient No trial
NA
Manipulation versus massage
Acute/subacute nonspecific
Pain intensity score (100-mm VAS)
Low Design: RCT ROB: High Consistency: NA (one trial) Directness: yes
In one trial [107], there was no significant difference between manipulation and massage immediately posttreatment (mean difference: and , resp.).
Acute/subacute specific
NA
Insufficient No trial
NA
Chronic nonspecific
Pain (duration of pain relief)
Low Design: RCT ROB: Medium Consistency: NA (one trial) Directness: no
In one trial [108], manipulation was significantly better than massage immediately—and in the short-term after treatment. The mean (SE) duration of pain relief was with manipulation versus with massage.
Chronic specific
NA
Insufficient No trial
NA
Mixed or unknown (specific, nonspecific)
NA
Insufficient No trial
NA
*Precision in formal grading was applied only to pooled results. VAS: visual analog scale; RMDQ: Roland-Morris disability scale; MPQ: McGill pain questionnaire; PDI: pain disability index; NPQ: neck pain questionnaire; NA: not applicable; ROB: risk of bias; RCT: randomized controlled trial.