Research Article

Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1

Table 3

Effect of Chinese herbal medicine on renal hemodynamics.

Treatment C L P A H a , b , d C L I n a , b , d C L S e c P A H a , b , d

Control3.32 ± 0.070.99 ± 0.032.34 ± 0.05
Cisplatin 2.04 ± 0.31*** 0.64 ± 0.08*** 1.40 ± 0.24***
Gui Zhi Fu Ling Wan 2.86 ± 0.21*0.97 ± 0.06 1.89 ± 0.16*
Liu Wei Di Huang Wan3.57 ± 0.141.05 ± 0.03 2.52 ± 0.14
Chia Wei Hsiao Yao San 2.88 ± 0.10*0.92 ± 0.03 1.96 ± 0.09*
Chi Chu Di Huang Wan3.16 ± 0.02 0.88 ± 0.04* 2.28 ± 0.02
Chih Po Di Huang Wan3.43 ± 0.060.89 ± 0.03 2.54 ± 0.04
Hsin I Ching Fei Tang3.28 ± 0.10 0.80 ± 0.03*** 2.48 ± 0.08
Lung Tan Hsieh Kan Tang3.14 ± 0.12 0.83 ± 0.04** 2.31 ± 0.13
Gui Zhi Fu Ling Wan HDc 2.70 ± 0.11**0.92 ± 0.03 1.79 ± 0.10**
Huang Qin3.50 ± 0.180.98 ± 0.03 2.52 ± 0.16
Huang Lien3.27 ± 0.181.00 ± 0.04 2.28 ± 0.15

aCLPAH = CLIn + CLSec PAH.
bResults were expressed as mean ± SE (mL/min/100 g BW) (n = 5–7).
cHD: high dose.
dStatistics: one-way ANOVA, LSD post-hoc; significantly different from control (*P < 0.05, **P < 0.005, ***P < 0.001).