Evaluation of Chinese-Herbal-Medicine-Induced Herb-Drug Interactions: Focusing on Organic Anion Transporter 1
Table 3
Effect of Chinese herbal medicine on renal hemodynamics.
Treatment
Control
3.32 ± 0.07
0.99 ± 0.03
2.34 ± 0.05
Cisplatin
2.04 ± 0.31***
0.64 ± 0.08***
1.40 ± 0.24***
Gui Zhi Fu Ling Wan
2.86 ± 0.21*
0.97 ± 0.06
1.89 ± 0.16*
Liu Wei Di Huang Wan
3.57 ± 0.14
1.05 ± 0.03
2.52 ± 0.14
Chia Wei Hsiao Yao San
2.88 ± 0.10*
0.92 ± 0.03
1.96 ± 0.09*
Chi Chu Di Huang Wan
3.16 ± 0.02
0.88 ± 0.04*
2.28 ± 0.02
Chih Po Di Huang Wan
3.43 ± 0.06
0.89 ± 0.03
2.54 ± 0.04
Hsin I Ching Fei Tang
3.28 ± 0.10
0.80 ± 0.03***
2.48 ± 0.08
Lung Tan Hsieh Kan Tang
3.14 ± 0.12
0.83 ± 0.04**
2.31 ± 0.13
Gui Zhi Fu Ling Wan HDc
2.70 ± 0.11**
0.92 ± 0.03
1.79 ± 0.10**
Huang Qin
3.50 ± 0.18
0.98 ± 0.03
2.52 ± 0.16
Huang Lien
3.27 ± 0.18
1.00 ± 0.04
2.28 ± 0.15
aCLPAH = CLIn + CLSec PAH.
bResults were expressed as mean ± SE (mL/min/100 g BW) (n = 5–7).
cHD: high dose.
dStatistics: one-way ANOVA, LSD post-hoc; significantly different from control (*P < 0.05, **P < 0.005, ***P < 0.001).