Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Figure 2

Effect of ethyl acetate extract of Saussurea involucrata (SI-2) or rutin on neuronal damage analysis in D-galactose-treated (aged) mice. Immunocytochemistry staining shows that cleaved caspase-3 (a) and cleaved PARP (b) in galactose-treated group were significantly increased compared with vehicle-treated group (PBS) and decreased in galatose + SI-2 (SI + D-gal) or rutin (Rutin) treated group compared with galatose (D-Gal) alone group in the CA1 subfield of hippocampus after 6 weeks of administration. (c) H&E staining for morphologicl analysis.