Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin

Figure 5

Protein expressions in the livers and fats of BLTW : CD1(ICR) mice after 4 weeks of diet exposure and triglycerides accumulation in HepG2 cells. (a) Protein expression of TNFα in livers of mice. (b) Protein expression of p-p65 in livers of mice. (c) Expression of the antioxidant protein MnSOD in livers of mice. (d) Expression of PEPCK in livers of mice. (e) Expression of GLUT4 in fats of mice. (f) Protein expression of pIKKα/β and p-p65 in HepG2 cells. (g) H₂O₂ induced triglycerides accumulation in HepG2 cells. 𝑛=3 per group; means ± SEM; Con: control mice; HF: mice fed with high fat and diet; HFCA or HC: HF mice treated with CAPA (CA); HFMET or HM: HF mice treated with metformin; *: 𝑃<0.05 versus Con; #: 𝑃<0.05 versus HF.

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