Research Article

Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth

Figure 2

Effect of harpalycin 2 (Har2) on enzymatic activity of sPLA2 from Bothrops pirajai (PrTX-III), Crotalus durissus terrificus (Cdt F15), Apis mellifera (Apis), and Naja naja (Naja) venom expressed as initial velocity of reaction after 20 min (Vo). (a) Native sPLA2 enzymatic activity and (b) harpalycin 2 treated sPLA2 enzymatic activity. Data expressed as mean ± S.E.M. and analyzed by ANOVA followed by Dunnett’s test, with *P set at 0.05.
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