Research Article

Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth

Table 1

Inhibition of enzymatic activity of proinflammatory enzymes by harpalycin-2.

EnzymesIC50 ( g/mL)

PrTX-III11.34
BPPLA211.90
HGVPLA227.42
COX-1131.90
COX-232.73
LOX 15HRC55.96
LOX 15SYN/D

Note: PrTX-III (piratoxin-III); BPPLA2 (bovine pancreas PLA2); HGVPLA2 (human group V PLA2); COX-1 (cyclooxygenase-1); COX-2 (cyclooxygenase-2); LOX 15HRC (Lipoxygenase 15hrc); LOX 15SY (Lipoxygenase 15sy). N/D (Not determined).