Enhanced Antidepressant-Like Effects of Electroacupuncture Combined with Citalopram in a Rat Model of Depression

Figure 3

Effects of 3 weeks of treatment with citalopram on CUS-induced depressive-like behavior. (a) Citalopram significantly increased sucrose preference at 10 and 20 mg/kg but not 5 mg/kg. (b) Citalopram remarkably increased sucrose intake without affecting the total fluid intake. (c) Citalopram at different doses (5, 10, and 20 mg/kg) had no effect on immobility, climbing, and swimming in the FST. (d)–(f) In the OFT, citalopram significantly increased horizontal (d) and vertical (e) movement distances and center entries (f) at 10 and 20 mg/kg but not 5 mg/kg. 𝑛=8-9 per group. Data represent mean ± SEM, ^∗𝑃<0.05, and ^∗∗𝑃<0.01  versus the vehicle-treated group.

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