Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation

Figure 1

CIG prevents cell morphological damage induced by WT/GFX in SK-N-SH cells. The cell morphology was observed under contrast microscope. Control: normal human neuroblastoma SK-N-SH cells; Con + CIG: 100 μg/mL CIG was incubated with normal SK-N-SH cells for 24 h; WT/GFX: SK-N-SH cells were exposed to 10 μM wortmannin/GF-109203X (WT/GFX) for 3 h; WT/GFX + CIG (L, M, and H): SK-N-SH cells were preincubated with CIG (50, 100, and 200 μg/mL) for 24 h and then exposed to 10 μM WT/GFX for 3 h after washing out CIG. Bar = 50 μm.