Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo

Figure 3

Effects of baicalin on TUNEL staining in the prefrontal cortex of MCAO mice. After 24 hr of MCAO, apoptotic cells ((a), ×400) were detected in regions of the prefrontal cortex. The apoptotic cells were labeled with red fluorescence, (A) sham group, (B) ischemia group, and (C) baicalin-treated group. Five animals were selected from each group and 3 sections were selected from each site. Five 400-fold fields of view were randomly selected from each section to quantify the mean of the positive cells. The results are expressed as the mean ± SEM (b). ^ΔΔ𝑃<0.01, ischemia group versus sham; **𝑃<0.01, baicalin-treated group versus ischemia group.

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