Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Table 2

Effect of garlic on blood pressure levels.

Study	Type	Target	Duration of Rx	Dose	Case/control	Outcome
Zhang et al., (2001) [48]	Parallel-controlled trial	Hypertensives	16 weeks	Distilled garlic oil 12.3 mg/d	14/13	Garlic oil lowers SBP and DBP
Dhawan and Jain, (2004) [49]	Not placebo controlled	Hypertensives	2 months	Garlic pearls 250 mg	20/20	Dec Bp, dec ox-LDL, and 8-iso-PGF2alpha levels
Capraz et al., (2007) [55]	Randomized placebo control trial	Hypertensives	70 minutes	Rw garlic, Garlic tablets	25/25/25	No effects on BP levels
Duda et al., (2008) [51]	Prospective and uncontrolled clinical study	Hypertensives	30 days	Antihypertensive drug + Garlic capsules	38/32	Dec total lipids and lipid peroxidation noticed
Ried et al., (2010) [50]	Randomized placebo control trial	Hypertensives	12 weeks	960 mg AGE	25/25	SBP—10.2 ± 4.3 mmHg dec
Ried et al., (2013) [53]	Double-blind, randomized placebo-controlled, dose-response trial	Hypertensives	12 weeks	Aged garlic 240/480/960 mg	26/26/27	SBP—11.8 ± 5.4 mmHg, (2 capsule) 7.4 ± 4.1 mmHg (4 capsule)

T. chol: total cholesterol, HDL: high density lipoprotein, TG: triglyceride, LDL: low-density lipoprotein, VLDL: very low-density lipoprotein, 8-OHdG: (8-Hydroxy-2′-deoxyguanosine), and 8-iso-PGF2alpha: (8-iso-Prostaglandin F2alpha).