Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes: A Signaling Response Mediated by Estrogen Receptor
Figure 5
The flavonoid-induced expressions of neurotrophic factors are blocked by inhibitor of estrogen receptor. Cultured astrocytes were serum starved for 3 hours with or without the pretreatment of ICI 182, 780 for another 3 hours, as in Figure 4. Astrocytes were pretreated with ICI 182, 780 (1 M) for 3 hours and then treated with flavonoids for 48 hours. The mRNA expression levels of neurotrophic factors were analyzed. Values are expressed as the fold of change ( basal) against the control (no treatment; set as 1), and in Mean SEM, , where .
