Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Table 2

Expression of angiogenesis-regulating genes correlating with IC₅₀ values of selected phytochemicals in the NCI panel of tumor cell lines (𝑅>0.3;𝑅<−0.3). The full names of the abbreviations given are listed in Supplementary Table  1.

Compound	Direct correlation with gene expression (𝑅>0.3)	Inverse correlation with gene expression (𝑅<−0.3)
Verbascoside	MPDZ, MMRN, F3, PECAM1, DDAH2, and NOTCH3, DVL3	NOS2A, C1QR1, PML, and STC1
Emodin	PECAM1, NID2	TIMP3, SNX17, TFPI2, SPR, and ANG
Apigenin	NRCAM	FGR2
Eriodictyol tetraacetate	FGFR2, SST, TEK, PML, and ANGPTL3	EFEMP1, C1QR1, PECAM1, STC1, and TGFB1
Resveratrol	TIMP3, EphA2, PLT, PIN, and COL4A2	FN1, PECAM1, PML, ABCG1, and CXCR4
Axitinib (control drug)	COL5A1, BPR2	THBS4