Effect of the Copaifera langsdorffii Desf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats
Light microscopy of the rat renal cortex and medulla revealed CaOx deposits in the lumen of renal tubules stained with silver nitrate. Copaiba leaf extract group: no calcium oxalate or histological alterations were observed ((a) and (b)). EG 1% group: glomerular degeneration, tubular necrosis, amorphous deposits in the tubular lumen, and several calcium oxalate deposits were detected ((c) and (d)). Post-stone treatment group: glomerular and tubular degenerations and calcium oxalate deposits were similar to those verified for EG 1% group ((e) and (f)). Prophylactic treatment group: glomerular and tubular degenerations were decreased in relation to EG 1% group, as well as the number of calcium oxalate deposits ((g) and (h)). (100x magnification).