Cardiovascular Protective Effects of Adjunctive Alternative Medicine (Salvia miltiorrhiza and Pueraria lobata) in High-Risk Hypertension

Table 3

Changes in vascular parameters at 6 and 12 months.

Vascular parameters	Baseline	6 months	12 months	𝑃 value^1	𝑃 value^2
FMD (%)
Placebo	5.5±1.3	5.9±1.2	6.2±1.1	0.001	0.0001
D&G (1 gm)	5.4±1.9	6.3±2.1	7.0±2.1	<0.0001	<0.0001
D&G (2 gm)	5.0±1.5	5.9±1.5	6.2±1.6	<0.0001	<0.0001
𝑃 value^3	0.850	0.411	0.088
𝑃 value^4	0.275	0.917	0.933
𝑃 value^5	0.465	0.693	0.347
IMT (mm)
Placebo	0.80±0.18	0.80±0.17	0.81±0.17	0.385	0.510
D&G (1 gm)	0.79±0.20	0.77±0.18	0.74±0.16	0.001	0.001
D&G (2 gm)	0.85±0.16	0.83±0.15	0.82±0.15	0.006	<0.0001
D&G (2 gm + 1 gm)	0.82±0.18	0.80±0.17	0.78±0.16	<0.0001	<0.0001
𝑃 value^3	0.850	0.457	0.130
𝑃 value^4	0.272	0.637	0.796
𝑃 value^5	0.607	0.037	0.001
NTG (%)
Placebo	15.2±2.5	15.6±2.4	15.9±3.1	0.276	0.510
D&G (1 gm)	16.0±2.8	16.7±3.0	16.7±3.3	0.376	0.914
D&G (2 gm)	15.4±3.3	15.9±3.2	16.1±3.1	0.198	0.301
𝑃 value^3	0.154	0.203	0.437
𝑃 value^4	0.901	0.684	0.882

1: 6 months versus baseline (paired 𝑡-test); 2: 12 months (paired 𝑡-test) versus baseline; 3: D&G (1 gm) versus placebo (ANOVA); 4: D&G (2 gm) versus placebo (ANOVA); 5: combined D + G (1 gm +2 gm) versus placebo (ANOVA).
D&G: Danshen + Gegen.
FMD: flow-mediated dilation.
IMT: intima-media thickness.
NTG: nitroglycerin-induced dilation.