Sulforaphane Attenuates Gentamicin-Induced Nephrotoxicity: Role of Mitochondrial Protection

Figure 7

SFN attenuates GM-induced necrosis of proximal tubules. (a–d) Representative renal histopathology of rats studied (H&E staining). Sections of renal cortex with loss in brush border of proximal tubular epithelium in (c) the GM group can be observed. Asterisks represent either obstruction of tubular lumen or complete loss in tubular structure. Arrows indicate flattening of tubular walls. Cross indicates edema. These alterations are considerably diminished in (d) the SFN + GM group. (a) CT and (b) SFN groups show normal histology (40x). Quantitative morphometry shows an important decrease in (e) damaged tubules and (f) damaged area per tubule in the SFN + GM group compared to the GM group. Data are mean±SEM. ^∗𝑃<0.001 versus GM.

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