A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by ¹H NMR-Based Metabonomics and the NF-𝜿B Pathway

Figure 4

OPLS-DA scores plots from the analyses of the processed NMR spectra. (a–c) cerebellum, (d–f) cortex, and (g–i) hippocampus tissue extracts derived from three groups of rats: red circle, control; black square, ischemia; green triangle, HSYA.

(a)  𝑅²𝑋=0.679,𝑅²𝑌=0.89,𝑄²=0.68

(b) 𝑅²𝑋=0.586,𝑅²𝑌=0.923,𝑄²=0.818

(c) 𝑅²𝑋=0.522,𝑅²𝑌=0.573,𝑄²=0.211

(d) 𝑅²𝑋=0.846,𝑅²𝑌=0.824,𝑄²=0.514

(e) 𝑅²𝑋=0.646,𝑅²𝑌=0.722,𝑄²=0.394

(f) 𝑅²𝑋=0.757,𝑅²𝑌=0.804,𝑄²=0.336

(g) 𝑅²𝑋=0.56,𝑅²𝑌=0.627,𝑄²=0.649

(h) 𝑅²𝑋=0.418,𝑅²𝑌=0.984,𝑄²=0.761

(i) 𝑅²𝑋=0.585,𝑅²𝑌=0.874,𝑄²=0.466