Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of Cassia alata L.

Table 1

Pharmacodynamic parameters (% relaxation at 1 mg/mL, EC₅₀ values, and potency (pEC₅₀)) and SEM obtained by nonlinear regression analysis of concentration-response curve for AECal, CF-AECal, EAF-AECal, and nBF-AECal in isolated rat trachea precontracted by acetylcholine (10 µM).

	AECal	PEF-AECal	CF-AECal	EAF-AECal	nBF-AECal
Contraction (% of max)	5.37 ± 1.37	98.79 ± 3.52	−9.67 ± 2.60	94.27 ± 5.69	98.47 ± 4.03
EC50 (CI)	0.54 (0.30–0.98)	nd	0.02 (0.02–0.03)	nd	nd
pEC50  ± SEM	0.27 ± 0.12	nd	1.60 ± 0.06	−1.47 ± 0.25	nd

Data are expressed as the mean ± SEM of 6–8 experiments. Significantly different from control: *𝑃 < 0.05, **𝑃 < 0.01, and ***𝑃 < 0.001.