Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana
Figure 2
The effect of sesquiterpene lactones on the growth of L. mexicana mexicana is blocked by adding of GSH. Parasites were incubated with the lactones; dehydroleucodine (DhL) (a), mexicanin I (Mxc) (b), psilostachyin (Psi) (c), or psilostachyin C (Psi C) (d) in the presence or in the absence of 1.5 mM glutathione (GSH), as indicated in the figure. Parasite counts were done daily. Glutathione alone did not affect the parasite growth (a).
