Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 163404, 6 pages
http://dx.doi.org/10.1155/2013/163404
Research Article

Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana

1Instituto de Histología y Embriología “Dr. Mario H. Burgos” (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo (UNCuyo), CC 56 (5500) Mendoza, Argentina
2Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 2°P, 1113 Buenos Aires, Argentina
3Instituto de Investigaciones en Tecnología Química (INTEQUI-CONICET), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, 5700 San Luis, Argentina

Received 9 April 2013; Accepted 20 May 2013

Academic Editor: William Setzer

Copyright © 2013 Patricia Barrera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, “Control of leishmaniases,” World Health Organization. Technical Report Series 949, 2010, http://www.who.int/leishmaniasis/en/. View at Google Scholar
  2. M. Khaw and C. B. Panosian, “Human antiprotozoal therapy: past, present, and future,” Clinical Microbiology Reviews, vol. 8, no. 3, pp. 427–439, 1995. View at Google Scholar · View at Scopus
  3. S. L. Croft, S. Sundar, and A. H. Fairlamb, “Drug resistance in leishmaniasis,” Clinical Microbiology Reviews, vol. 19, no. 1, pp. 111–126, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. O. Salomón, S. Acardi, D. Liotta et al., “Epidemiological aspects of cutaneous leishmaniasis in the Iguazú falls area of Argentina,” Acta Tropica, vol. 109, no. 1, pp. 5–11, 2009. View at Publisher · View at Google Scholar
  5. DNDi, “Drugs for Neglected Diseases Initiative. Leishmaniasis. Current treatments,” 2013, http://www.dndi.org/diseases-projects/diseases/vl/current-treatment.html.
  6. T. Schmidt, S. Khalid, A. Romanha et al., “The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases—part I,” Current Medicinal Chemistry, vol. 19, no. 14, pp. 2128–2175, 2012. View at Google Scholar
  7. M. M. Salem and K. A. Werbovetz, “Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis,” Current Medicinal Chemistry, vol. 13, no. 21, pp. 2571–2598, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Polonio and T. Efferth, “Leishmaniasis: drug resistance and natural products,” International Journal of Molecular Medicine, vol. 22, no. 3, pp. 277–286, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Lozano, P. Barrera, R. Salinas et al., “Sesquiterpene lactones and the diterpene 5-epi-icetexone affect the intracellular and extracellular stages of Trypanosoma cruzi,” Parasitology International, vol. 61, no. 4, pp. 628–633, 2012. View at Publisher · View at Google Scholar
  10. V. Sülsen, D. Gutierrez Yappu, L. Laurella et al., “In vitro antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 352938, 4 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. V. P. Sülsen, F. M. Frank, S. I. Cazorla et al., “Psilostachyin C: a natural compound with trypanocidal activity,” International Journal of Antimicrobial Agents, vol. 37, no. 6, pp. 536–543, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. V. Sülsen, P. Barrera, L. Muschietti, V. Martino, and M. Sosa, “Antiproliferative effect and ultrastructural alterations induced by psilostachyin on Trypanosoma cruzi,” Molecules, vol. 15, no. 1, pp. 545–553, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. V. P. Sülsen, F. M. Frank, S. I. Cazorla et al., “Trypanocidal and leishmanicidal activities of sesquiterpene lactones from Ambrosia tenuifolia Sprengel (Asteraceae),” Antimicrobial Agents and Chemotherapy, vol. 52, no. 7, pp. 2415–2419, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. A. Barrera, V. Jimenez-Ortiz, C. Tonn, O. Giordano, N. Galanti, and M. A. Sosa, “Natural sesquiterpene lactones are active against Leishmania mexicana,” Journal of Parasitology, vol. 94, no. 5, pp. 1143–1149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Jimenez-Ortiz, S. D. Brengio, O. Giordano et al., “The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes,” Journal of Parasitology, vol. 91, no. 1, pp. 170–174, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. S. D. Brengio, S. A. Belmonte, E. Guerreiro, O. S. Giordano, E. O. Pietrobon, and M. A. Sosa, “The sesquiterpene lactone dehydroleucodine (DhL) affects the growth of cultured epimastigotes of Trypanosoma cruzi,” Journal of Parasitology, vol. 86, no. 2, pp. 407–412, 2000. View at Google Scholar · View at Scopus
  17. B. Chawla and R. Madhubala, “Drug targets in Leishmania,” Journal of Parasitic Diseases, vol. 34, no. 1, pp. 1–13, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Cavalli and M. L. Bolognesi, “Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania,” Journal of Medicinal Chemistry, vol. 52, no. 23, pp. 7339–7359, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. O. S. Giordano, E. Guerreiro, M. J. Pestchanker, J. Guzman, D. Pastor, and T. Guardia, “The gastric cytoprotective effect of several sesquiterpene lactones,” Journal of Natural Products, vol. 53, no. 4, pp. 803–809, 1990. View at Google Scholar · View at Scopus
  20. J. Duranteau, N. S. Chandel, A. Kulisz, Z. Shao, and P. T. Schumacker, “Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes,” The Journal of Biological Chemistry, vol. 273, no. 19, pp. 11619–11624, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Beutler, O. Duron, and B. M. Kelly, “Improved method for the determination of blood glutathione,” The Journal of Laboratory and Clinical Medicine, vol. 61, pp. 882–888, 1963. View at Google Scholar · View at Scopus
  22. T. J. Schmidt, A. M. M. Nour, S. A. Khalid, M. Kaiser, and R. Brun, “Quantitative structure—antiprotozoal activity relationships of sesquiterpene lactones,” Molecules, vol. 14, no. 6, pp. 2062–2076, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Chaturvedi, “Sesquiterpene lactones: structural diversity and their biological activities,” in Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry, V. Tiwari and B. Mishra, Eds., pp. 313–334, Research Signpost, Kerala, India, 2011. View at Google Scholar
  24. V. B. Mathema, Y. Koh, B. C. Thakuri, and M. Sillanpää, “Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities,” Inflammation, vol. 35, pp. 560–565, 2012. View at Publisher · View at Google Scholar · View at Scopus