Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 2

Review Article

Best Available Evidence in Cochrane Reviews on Herbal Medicine?

Table 2

The eleven most relevant Cochrane reviews on herbal medicines extracted for confirmatory study design, ITT analysis, study duration, outcome measures, and numbers of different study medications.

Reference No. of
studies
Confirmatory
studies
ITT
analysis
Study
duration
Outcome measures No. of study
medications
PrimarySecondary

[3] (5/2011) 
Irritable bowel syndrome

Not stated if
hypothesis
clinically relevant
9 days to 18 wksGlobal improvement
of symptoms
Quality of life
No. of recurrent episodes
Predominant symptom
Cost-effectiveness
Adverse events

[4] (9/2012)  
Advanced colon cancer
7–126 days
Mean
54 days
Mortality**Survival time
Relative response

Oral
Injection

[5] (4/2006)  
Low back pain
Mean
3.5 weeks
Pain intensity, function
Overall improvement
Return to work

Oral
External

[6] (1/2009)  
Type 2 diabetes

Not stated if
hypothesis
clinically relevant
2–6 months
Mean
2.6 months
Mortality* 
Diabetic complications* 
Quality of life* 
Fasting glucose, HbA1C
BMI
Fasting insulin
AEs and costs

Oral
Injection

[7] (10/2005)  
Schizophrenia
20 days–6 monthsClinical response
subscores
Various

[8] (5/2012)  
Threatened Miscarriage
No dropouts
reported in
any study
Not stated
in all
Continuation of
pregnancy after
28 wks of gestation
During treatment
After treatment
Foetus

[9] (1/2010)  
Chronic neck pain
4 wksPain (VAS)
Functional status
Patient satisfaction
Neurologic outcomes
Adverse events

[10] (4/2006)  
Pre-eclampsia
Maternal: for example, death
Neonatal: for example, death
Various

[11] (11/2010)  
Primary dysmenorrhea
Up to
6 cycles
Approx. 6 months
Menstrual pain
Menstruation-related
symptoms, AEs
Laboratory values
Additional medications
Satisfaction

Oral
External
Rectal
Sublingual

[12] (6/2011)  
Diabetic neuropathy
At least
4 wks
30% improvement in
global score (e.g., VAS)
Quality of life
Nerve conduction
AEs

Oral
Injection
Either or

[13] (8/2011)  
Hyper
cholesterolaemia
Mean
2.3 months
Cardiovascular event
Serum cholesterol
Death, quality of life
Serum triglycerides,
BMI, AEs, and so forth

*In case of 5-year studies; **disease-related death/total recruited patients × 100%.