Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG

Table 1

Structures and activities of ugonins.

Compound name	Chemical structure	IC50 (μM)
		HFF-1 cells^a	MCF-7 cells^b	MDA-MB231 cells^b
Ugonin J		42.1	15.1	22.5
Ugonin K		41.0	15.7	22.9
Ugonin L		ND*	33.9	54.1
Ugonin P		>100	63.1	>100
Ugonin Q		100	>100	67.7
Ugonin R		ND	58.8	48.9
Ugonin S		ND	65.9	83.8
Ugonin M		>100	>100	>100
Ugonin N		100	65.5	67.2
Ugonin O		>100	>100	>100

∗ND: not determined. ^aHFF-1: human foreskin fibroblasts and ^bMCF-7/MDA-MB-231: human breast adenocarcinoma cell lines.