Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 170910, 9 pages
http://dx.doi.org/10.1155/2013/170910
Research Article

Low Frequency Electroacupuncture Alleviated Spinal Nerve Ligation Induced Mechanical Allodynia by Inhibiting TRPV1 Upregulation in Ipsilateral Undamaged Dorsal Root Ganglia in Rats

Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China

Received 25 May 2013; Accepted 24 June 2013

Academic Editor: Yong-Qing Yang

Copyright © 2013 Yong-Liang Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Baron, A. Binder, and G. Wasner, “Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment,” The Lancet Neurology, vol. 9, no. 8, pp. 807–819, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Baron, “Mechanisms of disease: neuropathic pain. A clinical perspective,” Nature Clinical Practice Neurology, vol. 2, no. 2, pp. 95–106, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Takeda, Y. Tsuboi, J. Kitagawa, K. Nakagawa, K. Iwata, and S. Matsumoto, “Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain,” Molecular Pain, vol. 7, article 5, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Palazzo, L. Luongo, V. de Novellis, L. Berrino, F. Rossi, and S. Maione, “Moving towards supraspinal TRPV1 receptors for chronic pain relief,” Molecular Pain, vol. 6, article 66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. K. M. Walker, L. Urban, S. J. Medhurst et al., “The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain,” Journal of Pharmacology and Experimental Therapeutics, vol. 304, no. 1, pp. 56–62, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Kanai, E. Nakazato, A. Fujiuchi, T. Hara, and A. Imai, “Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats,” Neuropharmacology, vol. 49, no. 7, pp. 977–984, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Vilceanu, P. Honore, Q. H. Hogan, and C. L. Stucky, “Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors,” Journal of Pain, vol. 11, no. 6, pp. 588–599, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Bernardini, W. Neuhuber, P. W. Reeh, and S. K. Sauer, “Morphological evidence for functional capsaicin receptor expression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse,” Neuroscience, vol. 126, no. 3, pp. 585–590, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. T. J. Price and C. M. Flores, “Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse,” Journal of Pain, vol. 8, no. 3, pp. 263–272, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Nicoletti, M. Trevisani, M. Manconi et al., “Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig,” Cephalalgia, vol. 28, no. 1, pp. 9–17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. T. J. Price, M. D. Louria, D. Candelario-Soto et al., “Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion,” BMC Neuroscience, vol. 6, article 4, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. J. D. Richardson and M. R. Vasko, “Cellular mechanisms of neurogenic inflammation,” Journal of Pharmacology and Experimental Therapeutics, vol. 302, no. 3, pp. 839–845, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Wang, Q. Guo, M. Wang, E. Wang, W. Zou, and J. Zhao, “Effect of intrathecal sufentanil and protein kinase C inhibitor on pain threshold and the expression of NMDA receptor/CGRP in spinal dorsal horn in rats with neuropathic pain,” Zhong Nan Da Xue Xue Bao Yi Xue Ban, vol. 37, no. 8, pp. 783–789, 2012. View at Google Scholar
  14. J.-S. Han, “Acupuncture analgesia: areas of consensus and controversy,” Pain, vol. 152, supplement, no. 3, pp. S41–S48, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Manni, F. Florenzano, and L. Aloe, “Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats,” Diabetologia, vol. 54, no. 7, pp. 1900–1908, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. H. S. Hwang, E. J. Yang, S. M. Lee, S. C. Lee, and S. M. Choi, “Antiallodynic effects of electroacupuncture combined with MK-801 treatment through the regulation of p35/p25 in experimental diabetic neuropathy,” Experimental Neurobiology, vol. 20, no. 3, pp. 144–152, 2011. View at Google Scholar
  17. R. Q. Sun, H. C. Wang, and Y. Wang, “Effect of electroacupuncture with different frequencies on neuropathic pain in a rat model,” Zhongguo Ying Yong Sheng Li Xue Za Zhi, vol. 18, no. 2, pp. 128–131, 2002. View at Google Scholar
  18. K. K. Sun, H. P. Jung, J. B. Sang et al., “Effects of electroacupuncture on cold allodynia in a rat model of neuropathic pain: mediation by spinal adrenergic and serotonergic receptors,” Experimental Neurology, vol. 195, no. 2, pp. 430–436, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Yu, C. Zhao, and X. Luo, “The effects of electroacupuncture on the extracellular signal-regulated kinase 1/2/P2X3 signal pathway in the spinal cord of rats with chronic constriction injury,” Anesthesia and Analgesia, vol. 116, no. 1, pp. 239–246, 2013. View at Google Scholar
  20. L. Aloe and L. Manni, “Low-frequency electro-acupuncture reduces the nociceptive response and the pain mediator enhancement induced by nerve growth factor,” Neuroscience Letters, vol. 449, no. 3, pp. 173–177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. H. Kim and J. M. Chung, “An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat,” Pain, vol. 50, no. 3, pp. 355–363, 1992. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. L. Hsieh, C. L. Lin, H. Chiang, Y. S. Fu, J. H. Lue, and S. T. Hsieh, “Role of peptidergic nerve terminals in the skin: reversal of thermal sensation by calcitonin gene-related peptide in TRPV1-depleted neuropathy,” PLoS ONE, vol. 7, no. 11, Article ID e50805, 2012. View at Google Scholar
  23. T. Shimizu, H. Toriumi, H. Sato et al., “Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat,” Brain Research, vol. 1173, no. 1, pp. 84–91, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Tang, Z. H. Li, S. N. Ge et al., “The inhibition of spinal astrocytic JAK2-STAT3 pathway activation correlates with the analgesic effects of triptolide in the rat neuropathic pain model,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 185167, 13 pages, 2012. View at Publisher · View at Google Scholar
  25. Y. L. Jiang, Y. Ning, Y. Y. Liu et al., “Effects of preventive acupuncture on streptozotocin-induced hyperglycemia in rats,” Journal of endocrinological investigation, vol. 34, no. 10, pp. e355–361, 2011. View at Google Scholar · View at Scopus
  26. M. Zimmermann, “Pathobiology of neuropathic pain,” European Journal of Pharmacology, vol. 429, no. 1–3, pp. 23–37, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. R.-D. Treede, T. S. Jensen, J. N. Campbell et al., “Neuropathic pain: redefinition and a grading system for clinical and research purposes,” Neurology, vol. 70, no. 18, pp. 1630–1635, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Abuduhadeer, “Neuropathic pain intensity depends on the degree of peripheral nerve injury in the rat,” Journal of Nippon Medical School, vol. 71, no. 6, pp. 399–407, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Costigan, J. Scholz, and C. J. Woolf, “Neuropathic pain: a maladaptive response of the nervous system to damage,” Annual Review of Neuroscience, vol. 32, pp. 1–32, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Montell, L. Birnbaumer, and V. Flockerzi, “The TRP channels, a remarkably functional family,” Cell, vol. 108, no. 5, pp. 595–598, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Zhang, C. Wang, G. Gu et al., “The effects of electroacupuncture at the ST36 (Zusanli) acupoint on cancer pain and transient receptor potential vanilloid subfamily 1 expression in walker 256 tumor-bearing rats,” Anesthesia and Analgesia, vol. 114, no. 4, pp. 879–885, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Szallasi and P. M. Blumberg, “Vanilloid (Capsaicin) receptors and mechanisms,” Pharmacological Reviews, vol. 51, no. 2, pp. 159–211, 1999. View at Google Scholar · View at Scopus
  33. T. King, C. Qu, A. Okun et al., “Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity,” Pain, vol. 152, no. 9, pp. 1997–2005, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Xu, N. T. Blair, and D. E. Clapham, “Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism,” Journal of Neuroscience, vol. 25, no. 39, pp. 8924–8937, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. A. C. Raddant and A. F. Russo, “Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation,” Expert Reviews in Molecular Medicine, vol. 13, article e36, 2011. View at Google Scholar · View at Scopus
  36. J. M. Jimenez-Andrade, A. P. Bloom, J. I. Stake et al., “Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain,” Journal of Neuroscience, vol. 30, no. 44, pp. 14649–14656, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Hirsch, L. Corradini, S. Just, K. Arndt, and H. Doods, “The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats,” Pain, vol. 154, no. 5, pp. 700–707, 2013. View at Google Scholar