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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 175135, 8 pages
http://dx.doi.org/10.1155/2013/175135
Review Article

Emerging Roles of Propolis: Antioxidant, Cardioprotective, and Antiangiogenic Actions

1Department of Basic and Experimental Nutrition, Institute of Nutrition, State University of Rio de Janeiro, 20559-900 Rio de Janeiro, RJ, Brazil
2Department of Clinical and Toxicology Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, SP, Brazil

Received 15 January 2013; Revised 19 March 2013; Accepted 20 March 2013

Academic Editor: Vassya Bankova

Copyright © 2013 Julio Beltrame Daleprane and Dulcinéia Saes Abdalla. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [29 citations]

The following is the list of published articles that have cited the current article.

  • Adriane Alexandre Machado De-Melo, Adriana Hitomi Matsuda, Alex da Silva de Freitas, Ortrud Monika Barth, and Ligia Bicudo de Almeida-Muradian, “Capacidade antioxidante da própolis,” Pesquisa Agropecuária Tropical, vol. 44, no. 3, pp. 341–348, 2014. View at Publisher · View at Google Scholar
  • Esfandiar Heidarian, Mahmoud Rafieian-Kopaei, Abolfazle Khoshdel, and Morteza Bakhshesh, “Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, pp. S429–S435, 2014. View at Publisher · View at Google Scholar
  • Kathleen G. Neiva, Dana L. Catalfamo, Shannon Holliday, Shannon M. Wallet, and Roberta Pileggi, “Propolis decreases lipopolysaccharide-induced inflammatory mediators in pulp cells and osteoclasts,” Dental Traumatology, 2014. View at Publisher · View at Google Scholar
  • Narayan D. Chaurasiya, Mohamed A. Ibrahim, Ilias Muhammad, Larry A. Walker, and Babu L. Tekwani, “Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B,” Molecules, vol. 19, no. 11, pp. 18936–18952, 2014. View at Publisher · View at Google Scholar
  • Vagner R. Santos, Rafael T. Gomes, Samara H. Iwanaga, Efigenia Ferreira E Ferreira, Ana C.C. Viana, Vladimir R.A.S. Noronha, Sheila R.L. Abreu, Gustavo S. Araújo, Maralice C. Barbosa, Evandro N. Abdo, and Alexandre A. Souza, “Mucoadhesive propolis gel for prevention of radiation-induced oral mucositis,” Current Clinical Pharmacology, vol. 9, no. 4, pp. 359–364, 2014. View at Publisher · View at Google Scholar
  • Milena Menegazzo Miranda, Rubens Cecchini, Jean Jerley Nogueira Da Silva, José Maurício Sforcin, Ivete Conchon-Costa, Wander Rogério Pavanelli, Carolina Panis, Allan Henrique Depieri Cataneo, Suelen Santos Da Silva, Natalia Yoshie Kawakami, Luiz Gonzaga De França Lopes, Alexandre Tadachi Morey, Lucy Megumi Yamauchi, and Célia Guadalupe Tardelli De Jesus Andrade, “Nitric oxide and Brazilian propolis combined accelerates tissue repair by modulating cell migration, cytokine production and collagen deposition in experimental leishmaniasis,” PLoS ONE, vol. 10, no. 5, 2015. View at Publisher · View at Google Scholar
  • Marcus Felipe Bezerra da Costa, Alexandre Braga Libório, Flávio Teles, Conceição da Silva Martins, Pedro Marcos Gomes Soares, Gdayllon C. Meneses, Francisco Adelvane de Paulo Rodrigues, Luzia Kalyne Almeida Moreira Leal, Diogo Miron, Aline Holanda Silva, and Alice Maria Costa Martins, “Red propolis ameliorates ischemic-reperfusion acute kidney injury,” Phytomedicine, 2015. View at Publisher · View at Google Scholar
  • Carmem Regine Faleiro Rodrigues, Luciana Ciarelli Plentz, Maria Cristina Marcucci, Rafael Rodrigues Dihl, and Mauricio Lehmann, “In vivo evaluation of mutagenic and recombinagenic activities of Brazilian propolis,” Food and Chemical Toxicology, 2016. View at Publisher · View at Google Scholar
  • Ambreen Shabbir, Maryam Rashid, and Hamid N Tipu, “Propolis, A Hope for the Future in Treating Resistant Periodontal Pathogens.,” Cureus, vol. 8, no. 7, 2016. View at Publisher · View at Google Scholar
  • Irlan Almeida Freires, Severino Matias de Alencar, and Pedro Luiz Rosalen, “A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases,” European Journal of Medicinal Chemistry, 2016. View at Publisher · View at Google Scholar
  • Cinthia Cristina Sousa de Menezes da Silveira, Luanna Melo Pereira Fernandes, Mallone Lopes Silva, Diandra Araújo Luz, Antônio Rafael Quadros Gomes, Marta Chagas Monteiro, Christiane Schineider Machado, Yohandra Reyes Torres, Tatiana Onofre de Lira, Antonio Gilberto Ferreira, Enéas Andrade Fontes-Júnior, and Cristiane Socorro Ferraz Maia, “Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  • Kemal Kismet, Cigdem Ozcan, Serdar Kuru, Omur Gencay Celemli, Pinar Celepli, Mehmet Senes, Tuncay Guclu, Kadriye Sorkun, Sema Hucumenoglu, and Tanju Besler, “Does propolis have any effect on non-alcoholic fatty liver disease?,” Biomedicine & Pharmacotherapy, vol. 90, pp. 863–871, 2017. View at Publisher · View at Google Scholar
  • Lauren Seabrooks, and Longqin Hu, “Insects: an underrepresented resource for the discovery of biologically active natural products,” Acta Pharmaceutica Sinica B, 2017. View at Publisher · View at Google Scholar
  • Cuiping Zhang, Xiaoge Shen, Jiawei Chen, Xiasen Jiang, and FuLiang Hu, “Identification of Free Radical Scavengers from Brazilian Green Propolis Using Off-Line HPLC-DPPH Assay and LC-MS,” Journal of Food Science, 2017. View at Publisher · View at Google Scholar
  • Karina D. Hamilton, Peter R. Brooks, Steven M. Ogbourne, and Fraser D. Russell, “Natural products isolated from Tetragonula carbonaria cerumen modulate free radical-scavenging and 5-lipoxygenase activities in vitro,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Flavia Regina Sobreira Corrêa, Fernanda Seabra Schanuel, Nathalia Moura-Nunes, Andréa Monte-Alto-Costa, and Julio Beltrame Daleprane, “Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFκB,” Biomedicine & Pharmacotherapy, vol. 86, pp. 162–171, 2017. View at Publisher · View at Google Scholar
  • Parimah Ebadi, and Mehdi Fazeli, “Anti-photoaging potential of propolis extract in UVB-irradiated human dermal fibroblasts through increasing the expression of FOXO3A and NGF genes,” Biomedicine & Pharmacotherapy, vol. 95, pp. 47–54, 2017. View at Publisher · View at Google Scholar
  • Romana Ahmed, E. M. Tanvir, Md. Sakib Hossen, Rizwana Afroz, Istiyak Ahmmed, Nur-E-Noushin Rumpa, Sudip Paul, Siew Hua Gan, Siti Amrah Sulaiman, and Md. Ibrahim Khalil, “Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–11, 2017. View at Publisher · View at Google Scholar
  • Liping Sun, Kai Wang, Xiang Xu, Miaomiao Ge, Yifan Chen, and Fuliang Hu, “Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Muhaimin Rifa’I, and Febby Nurdiya Ningsih, “Propolis action in controlling activated T cell producing TNF-α and IFN-γ in diabetic mice,” Turkish Journal of Immunology, vol. 5, no. 2, pp. 36–44, 2017. View at Publisher · View at Google Scholar
  • Sandra Kalthoff, and Christian P. Strassburg, “Contribution of human UDP-glucuronosyltransferases to the antioxidant effects of propolis, artichoke and silymarin,” Phytomedicine, 2018. View at Publisher · View at Google Scholar
  • Yaneth M. Monroy, Rodney A.F. Rodrigues, Marili V.N. Rodrigues, and Fernando A. Cabral, “Fractionation of ethanolic and hydroalcoholic extracts of green propolis using supercritical carbon dioxide as an anti-solvent to obtain artepillin rich-extract,” The Journal of Supercritical Fluids, 2018. View at Publisher · View at Google Scholar
  • Ahmad Oryan, Esmat Alemzadeh, and Ali Moshiri, “Potential role of propolis in wound healing: Biological properties and therapeutic activities,” Biomedicine & Pharmacotherapy, vol. 98, pp. 469–483, 2018. View at Publisher · View at Google Scholar
  • Jin Kim, and Chang-Moon Lee, “Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model,” Macromolecular Research, 2018. View at Publisher · View at Google Scholar
  • S. V. Pylypenko, A. A. Koval, and V. V. Makarchuk, “Impact Of Multiprobiotics On The Content Of Tba-Reactive Substances In The Blood Serum And Mucous Membranes Of The Stomach And Colon In Rats With Long-Term Gastric Hypochlorhydria,” World of Medicine and Biology, vol. 14, no. 65, pp. 218, 2018. View at Publisher · View at Google Scholar
  • Caroline Cristina Fernandes da Silva, Antonio Salatino, Lucimar Barbosa da Motta, Giuseppina Negri, and Maria Luiza Faria Salatino, “Chemical characterization, antioxidant and anti-HIV activities of a Brazilian propolis from Ceará state,” Revista Brasileira de Farmacognosia, 2019. View at Publisher · View at Google Scholar
  • Caroline Cristina Fernandes da Silva, Antonio Salatino, Lucimar Barbosa da Motta, Giuseppina Negri, and Maria Luiza Faria Salatino, “Chemical characterization, antioxidant and anti-HIV activities of a Brazilian propolis from Ceará state,” Revista Brasileira de Farmacognosia, 2019. View at Publisher · View at Google Scholar
  • Simona Martinotti, Giorgia Pellavio, Umberto Laforenza, and Elia Ranzato, “Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing,” Molecules, vol. 24, no. 8, pp. 1544, 2019. View at Publisher · View at Google Scholar
  • Camila de Carvalho Juanes, Susana Moreira de Souza, Vanessa Nogueira Lages Braga, Francisco Stefânio Barreto, Gisele Rocha Aguiar, Kleison Douglas Gomes Pimentel, Francisco Vagnaldo Fechine, and Conceição Aparecida Dornelas, “Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells,” Einstein (São Paulo), vol. 17, no. 2, 2019. View at Publisher · View at Google Scholar