Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats
Figure 5
The interindividual differences in the extent of changes in the AUC and CL of MDZ by baicalin. The changes in the ((a), (c)) and CL ((b), (d)) of MDZ (10 mg/kg, i.v.) in rats after treatment with baicalin at a single dose of 0.225 g/kg () or 0.45 g/kg () or at a dose of 0.90 g/kg once for 1 day and the same dose for 7 days ().
