Research Article

Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats

Table 1

Pharmacokinetic parameters of baicalin after intravenous administration in rats.

Baicalin (0.225 g/kg)Baicalin (0.45 g/kg)Baicalin (0.90 g/kg)
SingleMultiplea

(mg/L)
(h)
V (L/kg)
CL (L/h/kg)
(mg·h/L)
(mg·h/L)

Once daily for 7 days. Rats received intravenous administration of baicalin at a single dose of 0.225 or 0.45 g/kg ( ) or at a dose of 0.90 g/kg once for 1 day and the same dose for 7 days . The results were means SD of the indicated number of rats.