Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 6

Research Article

Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Table 6

Effects of GE on the expression of genes in adipose tissue.

Genes investigatedND240HFD60HFD120HFD240HFDMET

Lipolysis
 ATGL 1.78 ± 0.67a6.05 ± 0.42c5.69 ± 0.34c3.84 ± 0.98b
 HSL1.98 ± 0.072.99 ± 0.17a6.73 ± 0.42c6.54 ± 0.32c4.63 ± 1.16b

Differentiation
 LPL−1.05 ± 0.09 −1.93 ± 0.18a−1.12 ± 0.42b−1.17 ± 0.47b−2.22 ± 0.99a
 PPAR- −1.69 ± 0.19−2.08 ± 0.69a−1.69 ± 0.48ab−1.02 ± 0.36c−1.07 ± 0.16c
 SREBP-1c−1.27 ± 0.65−1.01 ± 0.16c−3.10 ± 0.44a −2.25 ± 0.30ab−2.30 ± 1.13ab

Results are expressed as fold variation over the appropriate control groups; ND240 indicates fold increase over ND (normal diet control group), and HFD60, HFD120, HFD240, and HFDMET indicate fold increase over HFD (high-fat diet control group). Fold variations less than one were expressed as negative numbers (e.g., a fold variation of 0.50 is expressed as −2.00). Values expressed are means ± S.D of triplicate measurements. Statistical significance was calculated based on the mean CT values by DMRT for only mice fed with high-fat diet with or without GE. For same gene with various treatment groups, superscripts in the different bar with different alphabets (a–c) were significantly different ( ). Superscripts with same alphabets were not significantly different between the treated groups ( ).

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