Bai-Hu-Tang, Ancient Chinese Medicine Formula, May Provide a New Complementary Treatment Option for Sepsis

Table 2

Linear regression model of association between different doses of BHT and cytokine changes.

	Change of IL-6^b			Change of IL-10^b
	𝛽	𝑃 value	𝑃 for trend	𝛽	𝑃 value	𝑃 for trend
Dose of BHT	−2.09		<0.001*	−1.39		<0.001*
High dose (1)^a	−2.13	<0.001*		−1.41	<0.001*
Low dose (0.5)^a	−0.39	0.295		−0.38	0.081

^aOrdinal variable: coding the early administration of high-dose BHT (CLP + BHT-H₆) as “1,” and the early administration of low-dose BHT administration (CLP + BHT-L₆) as “0.5”.
^bchanges of IL-6 and IL-10: subtracting the plasma levels of cytokines at baseline from those at 12 hrs postoperatively.
All cytokine changed values were natural log transformed.
^∗𝑃 < 0.05.