Bai-Hu-Tang, Ancient Chinese Medicine Formula, May Provide a New Complementary Treatment Option for Sepsis

Table 3

Cox proportional hazards models of survival rates for different doses of BHT and changes of IL-6 and IL-10.

Covariate	Unadjusted		Adjusted^+
	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value
Dose of BHT
High dose (1)^a	0.08 (0.01–0.73)	0.025*	0.56 (0.02–20.17)	0.751
Low dose (0.5)^a	0.26 (0.06–1.19)	0.083	0.25 (0.05–1.40)	0.115
Sepsis control (0)^a			Reference
Cytokine changes
Change of IL-6^b	3.58 (1.50–8.56)	0.004*	3.87 (1.03–14.53)	0.045*
Change of IL-10^b	4.56 (1.50–13.84)	0.007*	0.82 (0.10–6.91)	0.851

^aOrdinal variable: coding the early administration of high-dose BHT (CLP + BHT-H₆) as “1,” and the early administration of low-dose BHT administration (CLP + BHT-L₆) as “0.5”.
^bChanges of IL-6 and IL-10: subtracting the plasma levels of cytokines at baseline from those at 12 hrs postoperatively.
All values were natural log transformed.
Unadjusted: univariate Cox proportional hazards model.
Adjusted⁺: for different doses of BHT, changes of IL-6 and IL-10.
HR: hazard ratio, CI: confidence interval, ^∗𝑃< 0.05.