An Aqueous-Ethanol Extract of Liriope spicata var. prolifera Ameliorates Diabetic Nephropathy through Suppression of Renal Inflammation

Table 1

Biochemical parameters in experimental animals at the end of the eight-week treatment.

	Normal rats	STZ-diabetic rats
	Vehicle	Vehicle	TRLS-ext 100	TRLS-ext 200
Body weight (BW) (g rat^−1)	411.16±17.23^d	267.73±16.47^b	293.61±16.25^b,c	342.02±18.47^a,c
Kidney weight (KW) (g)	1.44±0.21^d	2.86±0.38^b	2.05±0.27^a,c	1.78±0.22^d
KW/BW ratio (%)	0.35±0.11^d	1.07±0.13^b	0.71±0.09^b,c	0.52±0.08^d
Plasma glucose (mg dL^−1)	94.83±7.92^d	436.29±17.28^b	352.87±15.26^b,c	311.26±14.38^b,c
HbA1c (%)	4.85±1.06^d	14.61±1.82^b	12.24±1.47^b	11.04±1.16^b
24-h urine volume (mL per day)	8.98±3.12^d	27.32±4.23^b	17.67±5.14^b,c	15.37±4.26^b,c
24-h urine protein (mg per day)	6.68±3.44^d	30.72±6.01^b	16.08±4.02^b,c	12.02±4.99^b,c
Scr (𝜇mol L^−1)	36.21±5.97^d	90.59±8.47^b	80.41±7.43^b	65.18±8.35^b,c
BUN (mmol L^−1)	6.72±1.71^c	17.46±1.93^b	14.10±2.01^b	10.78±1.63^a,c
Ccr (mL min^−1)	3.92±0.71^d	1.66±0.82^b	2.38±0.74^a,c	2.76±0.67^d

STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 100 mg kg⁻¹ TRLS-ext (TRLS-ext 100) or 200 mg kg⁻¹ TRLS-ext (TRLS-ext 200). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to disperse TRLS-ext. Values (mean ± SD) were obtained for each group of 8 animals. ^a𝑃<.05 and ^b𝑃<.01 compared to the values of vehicle-treated normal rats. ^c𝑃<.05 and ^d𝑃<.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.