Research Article

Electroacupuncture at 2/100 Hz Activates Antinociceptive Spinal Mechanisms Different from Those Activated by Electroacupuncture at 2 and 100 Hz in Responder Rats

Figure 5

Time course of the changes induced by intrathecal neostigmine (neo) or saline (10 μL) on antinociception induced by sham (open symbols) or real (black symbols) electroacupuncture (EA) at 2 (a), 100 (b), or 2/100 (c) Hz frequency on the tail-flick latency of rats anesthetized with isoflurane. Anesthesia was performed during the period indicated by a horizontal dashed arrow. Neostigmine (0.1 or 0.2 μg/10 μL) was injected at the time indicated by a vertical arrow. EA was applied for 20 minutes (horizontal line). Points are means (± SD) of 6 rats per group. compared to saline/sham EA (*) or any other group (#) using the Bonferroni post hoc test.
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