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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 243568, 12 pages
Review Article

Adjunct Methods of the Standard Diabetic Foot Ulceration Therapy

1Department of General and Gastrointestinal Surgery, Silesian Medical University, 41-902 Bytom Katowice, Poland
2Department of Internal Medicine, Silesian Medical University, 41-902 Bytom Katowice, Poland
3Department of Biochemistry, Silesian Medical University, 41-800 Zabrze Katowice, Poland

Received 5 February 2013; Revised 13 May 2013; Accepted 29 May 2013

Academic Editor: Wen-Chin Yang

Copyright © 2013 Dariusz Waniczek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The outcome of management of diabetic foot ulceration (DFU) is poor and insufficient. DFU therapy includes the standard management as debridement of the wound, revascularization procedures, off-loading of the ulcer and antibacterial actions, and supplementation of growth factors and cytokines, leading to stimulation of granulation, epidermization, and angiogenesis. The aim of the present review is to summarize the adjunct methods of the standard DFU therapy as hyperbaric oxygen therapy (HBOT), maggot therapy (MT), and platelet-rich plasma therapy (PRPT). The results of preclinical and clinical trials indicated that the methods may reduce time of therapy, short-term morbidity, and the risk of major amputation.