Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of Met/PI3k/Akt Pathway and Induction of Apoptosis
Figure 3
Bufalin combined with BIBW2992 overcomes HGF-triggered resistance to irreversible EGFR-TKIs in H1975 cells. (a) H1975 cells were treated with various concentrations of bufalin, with or without HGF (30 ng) for 72 h. (b) H1975 cells were treated with various concentrations of BIBW2992, with or without bufalin (20 μM) for 72 h, in the presence or absence of HGF (30 ng). Cell growth was determined by MTT assay. Error bars indicate SD.
