Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 4 / Research Article
Bioinformatics Analysis for the Antirheumatic Effects of Huang-Lian-Jie-Du-Tang from a Network Perspective Table 4 The network topology analysis about the overlapped genes and target proteins of HLJDT. It mainly included degree of distribution, betweenness, and K-core analysis.
Gene Degree Betweenness K-coreness RA disease gene Targeted by component of HLJDT IL6 84 0.059 20 Y Berberine; coptisine; wogonin IFNG 75 0.047 20 Y Berberine IL1B 63 0.029 20 Y Berberine; coptisine JUN 59 0.016 20 Y Berberine; wogonin IL8 58 0.026 20 Y Berberine; wogonin VEGFA 51 0.027 20 Y Baicalein; berberine FOS 51 0.024 20 Y Baicalein; berberine IL4 50 0.014 20 Y Berberine CCL2 41 0.006 20 Y Berberine; wogonin CXCL12 33 0.009 19 Y Berberine NOS2 9
9 Y Berberine; coptisine; wogonin TNF 6
6 Y Berberine; coptisine; wogonin RELA 56 0.012 20 N Baicalein; berberine; wogonin SRC 48 0.026 20 N Baicalein IL2RA 44 0.003 20 N Berberine MAPK1 42 0.016 20 N Berberine NFKBIA 42 0.008 20 N Berberine AKT1 42 0.010 20 N Baicalein; wogonin MMP9 38 0.0130 20 N Baicalein EGFR 35 0.004 20 N Berberine FN1 34 0.010 15 N Wogonin BCL2 33 0.004 20 N Baicalein; berberine; geniposide; wogonin PTGS2 30 0.004 20 N Baicalein; berberine; coptisine; wogonin RAC1 26 0.002 19 N Berberine APP 24 0.006 16 N Berberine TP53 24 0.007 18 N Baicalein; berberine; wogonin KDR 22 0.003 15 N Wogonin NFATC1 20 0.003 18 N Baicalein
