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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 263757, 10 pages
http://dx.doi.org/10.1155/2013/263757
Research Article

Metabolomic Analysis of Complex Chinese Remedies: Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid

1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan
2The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan
3Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan
4Department of Pharmacy, College of Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan
5Department of Computer Science and Information Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan
6Sheng Chang Pharmaceutical Co., Ltd., Jung-Li, Taiwan

Received 8 January 2013; Revised 26 February 2013; Accepted 27 February 2013

Academic Editor: Mark Moss

Copyright © 2013 Dong-Ming Tsai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [13 citations]

The following is the list of published articles that have cited the current article.

  • Ying-Yong Zhao, and Rui-Chao Lin, “Metabolomics in Nephrotoxicity,” vol. 65, pp. 69–89, 2014. View at Publisher · View at Google Scholar
  • Jean-Marie Colet, “Metabonomics in the preclinical and environmental toxicity field,” Drug Discovery Today: Technologies, vol. 13, pp. 3–10, 2015. View at Publisher · View at Google Scholar
  • Jian Shi, Bei Cao, Xin-Wen Wang, Ji-Ye Aa, Jin-Ao Duan, Xuan-Xuan Zhu, Guang-Ji Wang, and Chang-Xiao Liu, “Metabolomics and its application to the evaluation of the efficacy and toxicity of traditional Chinese herb medicines,” Journal of Chromatography B, 2015. View at Publisher · View at Google Scholar
  • Le Tao, Yigang Zeng, Jun Wang, Zhihong Liu, Bing Shen, Jifu Ge, Yong Liu, Yifeng Guo, and Jianxin Qiu, “Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo,” Molecular Medicine Reports, vol. 12, no. 5, pp. 6533–6546, 2015. View at Publisher · View at Google Scholar
  • Tsai-Kun Wu, Chyou-Wei Wei, Ying-Ru Pan, Shur-Hueih Cherng, Wei-Jung Chang, Hsueh-Fang Wang, and Yung-Luen Yu, “Vitamin C attenuates the toxic effect of aristolochic acid on renal tubular cells via decreasing oxidative stress-mediated cell death pathways,” Molecular Medicine Reports, vol. 12, no. 4, pp. 6086–6092, 2015. View at Publisher · View at Google Scholar
  • Hui Song, Chao-Lin Tang, Hong-Ye Zhang, Zhi-Heng Su, Hua Zheng, Xia Qin, Jun-Xiang Ruan, Shi-Yin Lu, and Yong-Hong Liang, “1H-NMR based metabonomic approach to evaluate anti-coagulant effect of Danggui Sini decoction,” Zhongguo Zhongyao Zazhi, vol. 40, no. 20, pp. 4088–4093, 2015. View at Publisher · View at Google Scholar
  • Dan-Qian Chen, Hua Chen, Lin Chen, Dan-Dan Tang, Hua Miao, and Ying-Yong Zhao, “Metabolomic application in toxicity evaluation and toxicological biomarker identification of natural product,” Chemico-Biological Interactions, 2016. View at Publisher · View at Google Scholar
  • Aihua Zhang, Qi Liu, Hongwei Zhao, Xiaohang Zhou, Hui Sun, Yang Nan, Shiyu Zou, Chung Wah Ma, and Xijun Wang, “Phenotypic characterization of nanshi oral liquid alters metabolic signatures during disease prevention,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Délia C. M. Santos, Marta L. Lima, Juliano S. Toledo, Paula A. Fernandes, Marta M. G. Aguiar, Ángeles López-Gonzálvez, Lucas A. M. Ferreira, Ana Paula Fernandes, and Coral Barbas, “Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug,” Toxicol. Res., 2016. View at Publisher · View at Google Scholar
  • Jianguo Zhou, Xinlian Chen, Yingxian Cui, Wei Sun, Yonghua Li, Yu Wang, Jingyuan Song, and Hui Yao, “Molecular Structure and Phylogenetic Analyses of Complete Chloroplast Genomes of Two Aristolochia Medicinal Species,” International Journal of Molecular Sciences, vol. 18, no. 9, pp. 1839, 2017. View at Publisher · View at Google Scholar
  • Chunfei Wang, Liang Feng, Liang Ma, Haifeng Chen, Xiaobin Tan, Xuefeng Hou, Jie Song, Li Cui, Dan Liu, Juan Chen, Nan Yang, Jing Wang, Ying Liu, Bingjie Zhao, Gang Wang, Yuanli Zhou, and Xiaobin Jia, “Alisol A 24-Acetate and Alisol B 23-Acetate Induced Autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Markku Pasanen, and Kati Hanhinevapp. 165–178, 2017. View at Publisher · View at Google Scholar
  • Ying-Ru Pan, Yung-Luen Yu, Tsai-Kun Wu, Hsuh-Fang Wang, and Chyou-Wei Wei, “Vitamin E (α-tocopherol) ameliorates aristolochic acid-induced renal tubular epithelial cell death by attenuating oxidative stress and caspase-3 activation,” Molecular Medicine Reports, vol. 17, no. 1, pp. 31–36, 2018. View at Publisher · View at Google Scholar