Metabolomic Analysis of Complex Chinese Remedies: Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid
Figure 1
Representative histology (HE stain, magnification 400x) of kidney tissue from the different treatment groups. At 10 days in Experiment 1 ((a)–(c)), no significant alterations of renal tubules and glomeruli in control group (a). After treatment with medium dose of AA (5 mg/kg/day), kidneys revealed moderate to severe acute proximal tubular necrosis (b). After treatment with high dose of AA (7.5 mg/kg/day), kidneys showed moderately to severe acute proximal tubular necrosis (c). At 20 days in Experiment 2 ((d)–(f)), no significant alterations of renal tubules and glomeruli in control group (d). After treatment with Madouling, the kidney showed focal, slight acute proximal tubular degeneration with cellular swelling (e). The change in BFAJT showed acute proximal tubular hydropic degeneration which is similar to mice treated with Madouling (f) (both with AA dosage equivalent to 0.5 mg/kg/day).
