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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 268963, 7 pages
Review Article

Traditional Herbal Medicine: A Review of Potential of Inhibitory Hepatocellular Carcinoma in Basic Research and Clinical Trial

Zhidong Wang,1,2,3 Jun Li,2,3 Yuanyuan Ji,2,3 Peng An,3 Shu Zhang,1,2,3 and Zongfang Li1,2,3

1Department of General Surgery, The Second Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an 710004, China
2National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Xi’an 710004, China
3Shaanxi Province Engineering Research Center of Biotherapy and Translation Medicine, Xi’an 710004, China

Received 28 March 2013; Revised 23 June 2013; Accepted 25 June 2013

Academic Editor: Sookyung Lee

Copyright © 2013 Zhidong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although significantly develops in hepatocellular carcinoma (HCC), features of HCC remain an aggressive cancer with a dismal outcome. Traditional Chinese medicine (TCM), specifically Chinese herbal medicine (CHM), is one of the most popular complementary and alternative medicine modalities worldwide. The use of heat-clearing and detoxicating (Chinese named qingre jiedu) CHM has attracted great attention as an alternative antitumor including HCC considering its low toxicity and high activity. Together these reports indicate that CHM is a promising anti-HCC herbal remedy in basic research. For patients with advanced HCC, CHM including formula and single combined with transcatheter arterial chemoembolization or chemotherapy is able to decrease tumor growth and the side effect of toxicity and improve overall survival, quality of life, and immune function. Due to its abundance, low cost, and safety in consumption, CHM remains a species with tremendous potential for further investigation in HCC.