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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 272134, 7 pages
Research Article

Antiulcer Activity of Indigenous Plant Operculina turpethum Linn.

1Department of Pharmacology, Sathyabama University Dental College and Hospital, Sathyabama University, Jeppiaar Nagar, Rajiv Gandhi Road, Chennai, Tamilnadu 600 119, India
2Department of Pharmacology and Environmental Toxicology, Dr. ALM Post Graduate Institute of Basic Medical Science, University of Madras, Taramani Campus, Chennai, Tamilnadu 600 113, India

Received 26 July 2012; Revised 19 December 2012; Accepted 21 December 2012

Academic Editor: José Luis Ríos

Copyright © 2013 Vidya Ignatius et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.