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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 273582, 12 pages
Research Article

Bioactive Lipidic Extracts from Octopus (Paraoctopus limaculatus): Antimutagenicity and Antiproliferative Studies

1Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, 83000 Hermosillo, SON, Mexico
2Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, 83000 Hermosillo, SON, Mexico
3Rubio Pharma y Asociados, S.A. de C.V., Blvd. García Morales No. 330, 83210 Hermosillo, SON, Mexico
4Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, 83000 Hermosillo, SON, Mexico

Received 17 September 2012; Revised 4 December 2012; Accepted 5 December 2012

Academic Editor: Vernon A. Barnes

Copyright © 2013 Carolina Moreno-Félix et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fractions from an organic extract from fresh octopus (Paraoctopus limaculatus) were studied for biological activities such as antimutagenic and antiproliferative properties using Salmonella tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. A chloroform extract obtained from octopus tentacles was sequentially fractionated using thin layer chromatography (TLC), and each fraction was tested for antimutagenic and antiproliferative activities. Organic extract reduced the number of revertants caused by aflatoxin B1 showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. Based on the results obtained, the isolated fractions obtained from octopus contain compounds with chemoprotective properties that reduce the mutagenicity of AFB1 and proliferation of cancer cell lines.