Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent: Effects on Leishmania amazonensis and Possible Mechanisms of Action

Table 1

Chemical composition and retention indices of the constituents of Eugenia uniflora essential oil.

Constituents^a	RRI		% A^d
	Cal.^b	Lit.^c
Myrcene	989	988	0.19
Limonene	1026	1029	0.18
Linalool	1095	1095	0.16
(𝑍)-3-Hexenyl butyrate	1186	1184	0.10
Cuminaldehyde	1240	1238	0.10
δ-Elemene	1335	1338	1.32
α-Cubebene	1349	1345	0.10
β-Elemene	1390	1389	5.51
Sativene	1394	1390	0.06
(E)-Caryophyllene	1417	1417	4.33
trans-α-Bergamotene	1437	1432	0.05
γ-Elemene	1434	1434	14.25
Aromadendrene	1440	1439	0.07
α-Humulene	1455	1452	0.21
Alloaromadendrene	1462	1458	0.11
β-Chamigrene	1475	1476	0.38
Germacrene D	1482	1484	1.19
β-Selinene	1487	1489	0.70
Curzerene	1498	1499	47.3
γ-Cadinene	1513	1513	0.12
δ-Cadinene	1523	1522	0.28
Selina-3,7-(11)-diene	1546	1545	0.24
Germacrene B	1558	1559	0.45
Spathulenol	1578	1577	0.17
Caryophyllene oxide	1581	1582	0.13
Globulol	1585	1590	0.25
Viridiflorol	1590	1592	0.08
trans-β-Elemenone	1597	1601	10.4
Atractilona	1655	1657	2.38
Germacrone	1694	1693	1.51
Eudesm-7(11)-en-4-ol	1700	1700	0.33
Monoterpene hydrocarbons	0.37
Oxygenated monoterpenes	0.36
Sesquiterpene hydrocarbons	29.37
Oxygenated sesquiterpenes	62.55
Total	92.65

aCompounds listed in order of elution on the DB-5ms column. ^bRelative retention indices (RRIs) experimentally determined against n-alkanes by using the DB-5ms column. ^cRRIs reported in the literature [23, 24]. ^dContent expressed as percentages obtained by integration of the GC peak area.