Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent: Effects on Leishmania amazonensis and Possible Mechanisms of Action

Table 2

Anti-Leishmania and cytotoxic effects of Eugenia uniflora essential oil.

	Macrophage	Promastigote				Amastigote
	CC50 (μg·mL^−1)	IC50 (μg·mL^−1)			SI	IC50 (μg·mL^−1)	SI
	48 h	24 h	48 h	72 h		48 h
EuEO	45.3±2.45	6.96±1.02	3.04±0.75	1.75±0.53	14.9^a	1.92±0.8	23.59^b

aSI_pro (selectivity index) = CC₅₀ macrophages/IC₅₀ promastigote forms (48 h).
^bSI_ama (selectivity index) = CC₅₀ macrophages/IC₅₀ amastigote forms.