The Efficacy of Guanxinning Injection in Treating Angina Pectoris: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 4

Subgroups and sensitivity analysis on ECG outcomes.

	Group	Number of; RCTs	Number of; participants	OR	Wilcoxon; test	95% CI	Z	P (eff)	𝐼^2	𝜒^2	P (het)
M score	≤3	21	1995	2.47	W = 149	1.79, 3.41	5.53	<0.0001	52%	0.28	0.0025
	>3	17	1709	2.71	P = 0.3945	2.17, 3.39	8.77	<0.0001	0%	0	0.9136
Sample size	<93	23	1734	2.42	W = 127	1.93, 3.02	7.72	<0.0001	0%	0	0.9776
	≥93	15	1970	2.86	P = 0.1789	1.94, 4.21	5.33	<0.0001	67%	0.37	0.0002
Number of authors	1	19	1872	2.30	W = 140	1.72, 3.08	5.65	<0.0001	41%	0.16	0.0358
	>1	19	1832	2.98	P = 0.2428	2.34, 3.80	8.81	<0.0001	13%	0.04	0.4435
Publication year	≤2008	15	1268	2.49	W = 200	1.94, 3.20	7.17	<0.0001	0%	0	0.9538
	>2008	23	2436	2.68	P = 0.4200	1.99, 3.61	6.47	<0.0001	52%	0.26	0.0025
Trial date report	Reported	31	3069	2.43	W = 57	1.97, 3.00	8.29	<0.0001	34%	0.12	0.0511
	Not reported	7	635	3.67	P = 0.0548	2.36, 5.70	5.79	<0.0001	8%	0.03	0.5363
Baseline; comparison	Reported	34	3318	2.64	W = 85	2.14, 3.24	9.20	<0.0001	35%	0.12	0.0513
	Not reported	4	386	2.29	P = 0.4325	1.25, 4.19	2.68	0.0074	23%	0.09	0.2200
Adverse; events	Reported	19	1955	2.67	W = 192	2.16, 3.30	9.14	<0.0001	0%	0	0.8792
	Not reported	19	1749	2.54	P = 0.7480	1.80, 3.59	5.28	<0.0001	54%	0.31	0.0020
Follow-up; period (day)	≤14	27	2528	2.83	W = 129	2.34, 3.42	10.67	<0.0001	2%	0	0.7120
	>14	11	1176	2.21	P = 0.5407	1.37, 3.57	3.27	<0.0001	65%	0.39	0.0024
GXN daily	6–200 mL	38	3704	2.59	W = 707.5	2.14, 3.15	9.68	<0.0001	32%	0.11	0.0539
dosage (mL)	6–30 mL	37	3648	2.58	P = 0.9662	2.12, 3.14	9.45	<0.0001	33%	0.1175	0.0448
GXN daily	<20	4	352	1.89	𝜒^2 = 3.4288,	1.00, 3.55	1.96	0.0497	27%	0.1148	0.2425
dosage (mL)	20	24	2324	2.80	df = 2	2.14, 3.66	7.51	<0.0001	43%	0.1820	0.0246
	>20	10	1028	2.53	P = 0.1801	1.85, 3.46	5.81	<0.0001	14%	0.0365	0.5413
Types of angina	Stable	4	374	3.03	𝜒^2 = 0.7010	1.80, 5.09	4.18	<0.0001	0%	0	0.6688
	Unstable	16	1676	2.48	df = 2	1.95, 3.15	7.42	<0.0001	10%	0.02	0.2332
	Angina	18	1654	2.60	P = 0.7043	1.87, 3.61	5.68	<0.0001	46%	0.22	0.0191
Improvement	>50%	38	3704	2.59	W = 1050	2.14, 3.15	9.68	<0.0001	32%	0.11	0.0539
	>80%	38	3704	1.84	P < 0.0001	1.59, 2.14	8.06	<0.0001	0%	0	0.8367
GXN	1	3	188	3.15	𝜒^2 = 1.6604	1.71, 5.81	3.68	0.0002	0%	0	0.9202
GXN + CG	2	29	2963	2.68	df = 2	2.10, 3.41	7.98	<0.0001	42%	0.17	0.0157
GXN + CG + additional	3	6	553	2.09	P = 0.4360	1.45, 3.01	3.94	<0.0001	0%	0	0.6382

CI is confidence interval; Z and P (eff) are statistical terms for evaluating overall effect; 𝐼², 𝜒², and P (het) are statistical terms for assessing heterogeneity among studies.