The Efficacy of Guanxinning Injection in Treating Angina Pectoris: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Table 4
Subgroups and sensitivity analysis on ECG outcomes.
Group
Number of RCTs
Number of participants
OR
Wilcoxon test
95% CI
Z
P (eff)
P (het)
M score
≤3
21
1995
2.47
W = 149
1.79, 3.41
5.53
<0.0001
52%
0.28
0.0025
>3
17
1709
2.71
P = 0.3945
2.17, 3.39
8.77
<0.0001
0%
0
0.9136
Sample size
<93
23
1734
2.42
W = 127
1.93, 3.02
7.72
<0.0001
0%
0
0.9776
≥93
15
1970
2.86
P = 0.1789
1.94, 4.21
5.33
<0.0001
67%
0.37
0.0002
Number of authors
1
19
1872
2.30
W = 140
1.72, 3.08
5.65
<0.0001
41%
0.16
0.0358
>1
19
1832
2.98
P = 0.2428
2.34, 3.80
8.81
<0.0001
13%
0.04
0.4435
Publication year
≤2008
15
1268
2.49
W = 200
1.94, 3.20
7.17
<0.0001
0%
0
0.9538
>2008
23
2436
2.68
P = 0.4200
1.99, 3.61
6.47
<0.0001
52%
0.26
0.0025
Trial date report
Reported
31
3069
2.43
W = 57
1.97, 3.00
8.29
<0.0001
34%
0.12
0.0511
Not reported
7
635
3.67
P = 0.0548
2.36, 5.70
5.79
<0.0001
8%
0.03
0.5363
Baseline comparison
Reported
34
3318
2.64
W = 85
2.14, 3.24
9.20
<0.0001
35%
0.12
0.0513
Not reported
4
386
2.29
P = 0.4325
1.25, 4.19
2.68
0.0074
23%
0.09
0.2200
Adverse events
Reported
19
1955
2.67
W = 192
2.16, 3.30
9.14
<0.0001
0%
0
0.8792
Not reported
19
1749
2.54
P = 0.7480
1.80, 3.59
5.28
<0.0001
54%
0.31
0.0020
Follow-up period (day)
≤14
27
2528
2.83
W = 129
2.34, 3.42
10.67
<0.0001
2%
0
0.7120
>14
11
1176
2.21
P = 0.5407
1.37, 3.57
3.27
<0.0001
65%
0.39
0.0024
GXN daily
6–200 mL
38
3704
2.59
W = 707.5
2.14, 3.15
9.68
<0.0001
32%
0.11
0.0539
dosage (mL)
6–30 mL
37
3648
2.58
P = 0.9662
2.12, 3.14
9.45
<0.0001
33%
0.1175
0.0448
GXN daily
<20
4
352
1.89
= 3.4288,
1.00, 3.55
1.96
0.0497
27%
0.1148
0.2425
dosage (mL)
20
24
2324
2.80
df = 2
2.14, 3.66
7.51
<0.0001
43%
0.1820
0.0246
>20
10
1028
2.53
P = 0.1801
1.85, 3.46
5.81
<0.0001
14%
0.0365
0.5413
Types of angina
Stable
4
374
3.03
= 0.7010
1.80, 5.09
4.18
<0.0001
0%
0
0.6688
Unstable
16
1676
2.48
df = 2
1.95, 3.15
7.42
<0.0001
10%
0.02
0.2332
Angina
18
1654
2.60
P = 0.7043
1.87, 3.61
5.68
<0.0001
46%
0.22
0.0191
Improvement
>50%
38
3704
2.59
W = 1050
2.14, 3.15
9.68
<0.0001
32%
0.11
0.0539
>80%
38
3704
1.84
P < 0.0001
1.59, 2.14
8.06
<0.0001
0%
0
0.8367
GXN
1
3
188
3.15
= 1.6604
1.71, 5.81
3.68
0.0002
0%
0
0.9202
GXN + CG
2
29
2963
2.68
df = 2
2.10, 3.41
7.98
<0.0001
42%
0.17
0.0157
GXN + CG + additional
3
6
553
2.09
P = 0.4360
1.45, 3.01
3.94
<0.0001
0%
0
0.6382
CI is confidence interval; Z and P (eff) are statistical terms for evaluating overall effect; , , and P (het) are statistical terms for assessing heterogeneity among studies.